TNFRSF18 Protein (Fc Tag)
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- Target Alle TNFRSF18 Proteine anzeigen
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
- Protein-Typ
- Recombinant
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses TNFRSF18 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Recombinant Rat GITR/TNFRSF18 Protein (Fc Tag)
- Sequenz
- Met1-Lys121
- Produktmerkmale
- A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product TNFRSF18 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
- Andere Bezeichnung
- GITR/TNFRSF18 (TNFRSF18 Produkte)
- Synonyme
- GITR Protein, TNFRSF18 Protein, AITR Protein, Gitr Protein, CD357 Protein, GITR-D Protein, TNF receptor superfamily member 18 Protein, tumor necrosis factor receptor superfamily, member 18 Protein, TNFRSF18 Protein, Tnfrsf18 Protein
- Hintergrund
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Background: GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: TNFRSF18
- Molekulargewicht
- 37.7 kDa
- UniProt
- Q5M835
- Pathways
- Cancer Immune Checkpoints
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