TRIM5 Protein (His tag)

Produktnummer ABIN7319116

Produktdetails

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TRIM5 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human TRIM5/RNF88 Protein (His Tag)

Sequenz: Met 1-Gln248

Produktmerkmale: Recombinant Human Tripartite motif-containing protein 5 is produced by our E.coli expression system and the target gene encoding Met1-Gln248 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Andere Bezeichnung: TRIM5/RNF88 (TRIM5 Produkte)

Synonyme: TRIM5 Protein, RNF88 Protein, TRIM5alpha Protein, EG667823 Protein, Gm8833 Protein, RGD1304579 Protein, tripartite motif containing 5 Protein, tripartite motif-containing 5 Protein, TRIM5 Protein, Trim5 Protein

Hintergrund:

Background: Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of action has not been shown conclusively, but capsid protein from restricted viruses is removed by proteasome-dependent degradation

Synonym: Tripartite motif-containing protein 5,RING finger protein 88,TRIM5,RNF88

Molekulargewicht: 30.8 kDa

UniProt: Q9C035

Pathways: Activation of Innate immune Response