SMPDL3A Protein (His tag)

Produktnummer ABIN7319243

Produktdetails

Target: SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses SMPDL3A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human SMPDL3A Protein (His Tag)

Sequenz: Leu23-Tyr453

Produktmerkmale: Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a is produced by our Mammalian expression system and the target gene encoding Leu23-Tyr453 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))

Andere Bezeichnung: SMPDL3A (SMPDL3A Produkte)

Synonyme: ASM3A Protein, ASML3a Protein, yR36GH4.1 Protein, 0610010C24Rik Protein, AI529588 Protein, ASML3 Protein, ASML3A Protein, sphingomyelin phosphodiesterase acid like 3A Protein, sphingomyelin phosphodiesterase, acid-like 3A Protein, SMPDL3A Protein, Smpdl3a Protein

Hintergrund:

Background: Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.

Synonym: Acid Sphingomyelinase-Like Phosphodiesterase 3a, ASM-Like Phosphodiesterase 3a,SMPDL3A,ASML3A

Molekulargewicht: 49.9 kDa

UniProt: Q92484