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SMPDL3A Protein (Sphingomyelin phosphodiesterase, Acid-Like 3A) (AA 23-453) (His tag)

SMPDL3A Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1691722
$522.50
Zzgl. Versandkosten $45.00
Lieferung in 4 Werktagen
  • Target Alle SMPDL3A Proteine anzeigen
    SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 23-453
    Spezies
    • 2
    • 2
    • 1
    Human
    Quelle
    • 2
    • 1
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses SMPDL3A Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human ASM-Like Phosphodiesterase 3a/SMPDL3A (C-6His)
    Sequenz
    LPVAPAGGRN PPPAIGQFWH VTDLHLDPTY HITDDHTKVC ASSKGANASN PGPFGDVLCD SPYQLILSAF DFIKNSGQEA SFMIWTGDSP PHVPVPELST DTVINVITNM TTTIQSLFPN LQVFPALGNH DYWPQDQLPV VTSKVYNAVA NLWKPWLDEE AISTLRKGGF YSQKVTTNPN LRIISLNTNL YYGPNIMTLN KTDPANQFEW LESTLNNSQQ NKEKVYIIAH VPVGYLPSSQ NITAMREYYN EKLIDIFQKY SDVIAGQFYG HTHRDSIMVL SDKKGSPVNS LFVAPAVTPV KSVLEKQTNN PGIRLFQYDP RDYKLLDMLQ YYLNLTEANL KGESIWKLEY ILTQTYDIED LQPESLYGLA KQFTILDSKQ FIKYYNYFFV SYDSSVTCDK TCKAFQICAI MNLDNISYAD CLKQLYIKHN YVDHHHHHH
    Produktmerkmale
    Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a/SMPDL3A is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu23-Tyr453) of Human SMPDL3A fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Haltbarkeit
    5 months
  • Target
    SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))
    Andere Bezeichnung
    SMPDL3A (SMPDL3A Produkte)
    Synonyme
    ASM3A, ASML3a, yR36GH4.1, 0610010C24Rik, AI529588, ASML3, ASML3A, sphingomyelin phosphodiesterase acid like 3A, sphingomyelin phosphodiesterase, acid-like 3A, SMPDL3A, Smpdl3a
    Sub Type
    Fusionprotein
    Hintergrund
    Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR and LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses.
    Alternative Names:
    Molekulargewicht
    49.9 kDa
    UniProt
    Q92484
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