SIGIRR Protein (His tag,Fc Tag)
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- Target Alle SIGIRR Proteine anzeigen
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Protein-Typ
- Recombinant
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SIGIRR Protein ist gelabelt mit His tag,Fc Tag.
- Verwendungszweck
- Recombinant Mouse SIGIRR/TIR8 Protein (His & Fc Tag)
- Sequenz
- Met 1-His 117
- Produktmerkmale
- A DNA sequence encoding the mouse SIGIRR (NP_075546.2) (Met 1-His 117) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SIGIRR Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Andere Bezeichnung
- SIGIRR/TIR8 (SIGIRR Produkte)
- Synonyme
- TIR8 Protein, AI256711 Protein, sc:d148 Protein, RGD1306732 Protein, single Ig and TIR domain containing Protein, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Protein, SIGIRR Protein, Sigirr Protein, sigirr Protein
- Hintergrund
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Background: Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
Synonym: AI256711,TIR8
- Molekulargewicht
- 40.7 kDa
- NCBI Accession
- NP_075546
- Pathways
- Toll-Like Receptors Cascades
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