RPS6KA6 Protein (GST tag)

Produktnummer ABIN7317116

Produktdetails

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses RPS6KA6 Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human RSK4/RPS6KA6 Protein (GST Tag)

Sequenz: Met 1-Leu 745

Produktmerkmale: A DNA sequence encoding the full length of human RSK4 (NP_055311.1) (Met 1-Leu 745) was fused with the GST tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM Reduced Glutathione, 10 % glycerol, 0.5 mM PMSF, 0.5 mM EDTA, pH 8.0

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Andere Bezeichnung: RSK4/RPS6KA6 (RPS6KA6 Produkte)

Synonyme: PP90RSK4 Protein, RSK4 Protein, 2610524K04Rik Protein, RGD1560817 Protein, ribosomal protein S6 kinase A6 Protein, ribosomal protein S6 kinase polypeptide 6 Protein, RPS6KA6 Protein, Rps6ka6 Protein

Hintergrund:

Background: Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 90 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RPS6KA6 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RPS6KA6 plays a role in normal neuronal development. Further mutation analyses in males with X-linked mental retardation must prove that the gene of RPS6KA6 is indeed a novel MRX gene. RPS6KA6 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA6 is activated by multiple phosphorylations on threonine and serine residues.

Synonym: PP90RSK4;RSK4

Molekulargewicht: 110 kDa

NCBI Accession: NP_055311

Pathways: MAPK Signalweg