RTN4R Protein (His tag,Fc Tag)

Produktnummer ABIN7320405

Produktdetails

Target: RTN4R (Reticulon 4 Receptor (RTN4R))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses RTN4R Protein ist gelabelt mit His tag,Fc Tag.

Verwendungszweck: Recombinant Mouse Nogo Receptor/NgR Protein (His & Fc Tag)(Active)

Sequenz: Met 1-Ser 447

Produktmerkmale: A DNA sequence encoding the the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Reinheit: > 85 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse RTN4R Fc Chimera at 2 μg/ml (100 μl/well) can bind biotinylated human RTN4 (GST Tag) with a linear range of 0.16-2.5 μg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: RTN4R (Reticulon 4 Receptor (RTN4R))

Andere Bezeichnung: Nogo Receptor/NgR (RTN4R Produkte)

Synonyme: NgR Protein, NGR Protein, NOGOR Protein, NgR1 Protein, Nogor Protein, reticulon 4 receptor Protein, rtn4r Protein, RTN4R Protein, Rtn4r Protein

Hintergrund:

Background: Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

Synonym: NgR,NgR1,NOGOR,Rtn4r

Molekulargewicht: 73.8 kDa

NCBI Accession: NP_075358

Pathways: Neurotrophin Signalübertragung