PTK6 Protein (GST tag)

Produktnummer ABIN7317095

Produktdetails

Target: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses PTK6 Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human PTK6/Brk Protein (GST Tag)

Sequenz: Met 1-Thr 451

Produktmerkmale: A DNA sequence encoding the full length of human PTK6 (NP_005966.1) (Met 1-Thr 451) was fused with the GST tag at the N-terminus.

Reinheit: > 89 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: PTK6 (PTK6 Protein tyrosine Kinase 6 (PTK6))

Andere Bezeichnung: PTK6/Brk (PTK6 Produkte)

Synonyme: BRK Protein, Sik Protein, Tksk Protein, tks Protein, zgc:153964 Protein, protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6 Protein, PTK6 protein tyrosine kinase 6b Protein, PTK6 Protein, Ptk6 Protein, ptk6b Protein

Hintergrund:

Background: Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.

Synonym: BRK

Molekulargewicht: 78 kDa

NCBI Accession: NP_005966