PLGF Protein (His tag)

Produktnummer ABIN7319842

Produktdetails

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses PLGF Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Placenta Growth Factor/PGF/PIGF/PLGF (C-6His)

Sequenz: Leu19-Arg170

Produktmerkmale: Recombinant Human Placenta Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu19-Arg170 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Andere Bezeichnung: Placenta Growth Factor/PGF/PIGF/PLGF (PGF Produkte)

Synonyme: D12S1900 Protein, PGFL Protein, PLGF Protein, PlGF-2 Protein, SHGC-10760 Protein, AI854365 Protein, PIGF Protein, Plgf Protein, PlGF Protein, placental growth factor Protein, placenta growth factor Protein, PGF Protein, Pgf Protein, PLGF Protein

Hintergrund:

Background: Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF-1), 152 (PlGF-2), and 203 (PlGF-3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 - 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF (especially PlGF-1) and some forms of VEGF can form dimers that decrease the angiogenic effect of VEGF on VEGF R2. PlGF-2, like VEGF164/165, shows heparin-dependent binding of neuropilin (Npn)-1 and Npn-2, and can inhibit nerve growth cone collapse. Circulating PlGF often correlates with tumor stage and aggressiveness, and therapeutic PlGF-2 antibodies are being investigated for their ability to inhibit tumor growth and angiogenesis.

Synonym: PlGF2, PlGF-2, PGF, PLGF, PlGF2, PlGF, PGFL

Molekulargewicht: 18.2 kDa

Pathways: VEGFR1 Specific Signals