PFKM Protein (GST tag,His tag)

Produktnummer ABIN7197337

Produktdetails

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses PFKM Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Human PFK1/PFKM Protein (His & GST Tag)

Sequenz: Thr 2-Val 780

Produktmerkmale: A DNA sequence encoding the human PFKM (P08237-1) (Thr2-Val780) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Andere Bezeichnung: PFK1/PFKM (PFKM Produkte)

Synonyme: GSD7 Protein, PFK-1 Protein, PFK1 Protein, PFKA Protein, PFKX Protein, AI131669 Protein, PFK-A Protein, PFK-M Protein, Pfk-4 Protein, Pfk4 Protein, Pfka Protein, Pfkx Protein, Pfk-M Protein, M-PFK Protein, PFKM Protein, pfkm Protein, zgc:92344 Protein, pfk Protein, im:7137110 Protein, wu:fc58g11 Protein, phosphofructokinase, muscle Protein, phosphofructokinase, platelet Protein, phosphofructokinase, muscle a Protein, phosphofructokinase, muscle S homeolog Protein, phosphofructokinase, muscle b Protein, PFKM Protein, Pfkm Protein, PFKP Protein, pfkma Protein, pfkm.S Protein, pfkmb Protein

Hintergrund:

Background: PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-type isozyme. There are three phosphofructokinase isozymes in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Mutations in PFK1 gene have been related with glycogen storage disease type VII, also identified as Tarui disease.

Synonym: 6-phosphofructokinase, muscle type,Phosphofructo-1-kinase isozyme A,Phosphofructokinase 1,Phosphohexokinase,PFKM,PFKX,ATP-PFK,GSD7,PFK-1,PFK1,PFKA,PPP1R122

Molekulargewicht: 112.9 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effekt