PDE1C Protein (GST tag,His tag)

Produktnummer ABIN7197331

Produktdetails

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses PDE1C Protein ist gelabelt mit GST tag,His tag.

Verwendungszweck: Recombinant Human PDE1C Protein (His & GST Tag)

Sequenz: Met 1-Glu634

Produktmerkmale: A DNA sequence encoding the human PDE1C (Q8TAE4) (Met1-Glu634) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Andere Bezeichnung: PDE1C (PDE1C Produkte)

Synonyme: CG14940 Protein, CG14942 Protein, CG14943 Protein, CG14944 Protein, CG31757 Protein, CG31758 Protein, CG42325 Protein, CG44007 Protein, Dmel\\CG44007 Protein, Dmel_CG14940 Protein, Dmel_CG14943 Protein, Dmel_CG14944 Protein, Dmel_CG31757 Protein, Dmel_CG31758 Protein, Dmel_CG42325 Protein, PDE1C Protein, PDE1c Protein, GB13690 Protein, Hcam3 Protein, Phosphodiesterase 1c Protein, phosphodiesterase 1C Protein, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Protein, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Protein, phosphodiesterase 1C, calmodulin-dependent b Protein, Pde1c Protein, PDE1C Protein, LOC724389 Protein, LOC100019026 Protein, pde1cb Protein

Hintergrund:

Background: PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory. PDE1C has a high affinity for both cAMP and cGMP. It is expressed in several tissues, including brain and heart. As a cyclic nucleotide phosphodiesterase, PDE1C has a dual-specificity for the second messengers cAMP and cGMP.

Synonym: cam-PDE1C,hCam-3,Hcam3

Molekulargewicht: 100 kDa

UniProt: Q8TAE4

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma