Oncostatin M Receptor Protein (OSMR) (AA 28-739) (His tag)

Produktnummer ABIN7318848

Produktdetails

Target: Oncostatin M Receptor (OSMR)

Protein-Typ: Recombinant

Proteineigenschaft: AA 28-739

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Oncostatin M Receptor Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human OSMR/IL31RB Protein (aa 28-739, His Tag)

Sequenz: Glu28-Ser739

Produktmerkmale: Recombinant Human Oncostatin-M-Specific Receptor Subunit beta is produced by our Mammalian expression system and the target gene encoding Glu28-Ser739 is expressed with a 6His tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Oncostatin M Receptor (OSMR)

Andere Bezeichnung: OSMR/IL31RB (OSMR Produkte)

Synonyme: OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein

Hintergrund:

Background: Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.

Synonym: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR,OSMRB,PLCA1

Molekulargewicht: 82.0 kDa

UniProt: Q99650

Pathways: JAK-STAT Signalweg, Growth Factor Binding