KYNU Protein (His tag)

Produktnummer ABIN7196722

Produktdetails

Target: KYNU (Kynureninase (L-Kynurenine Hydrolase) (KYNU))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses KYNU Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human KYNU/Kynureninase Protein (His Tag)(Active)

Sequenz: Met 1- Asn 465

Produktmerkmale: A DNA sequence encoding the human KYNU (Q16719) (Met 1- Asn 465) was expressed with a polyhistidine tag at the C-terminus.

Reinheit: > 92 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 200 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 25 % gly

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: KYNU (Kynureninase (L-Kynurenine Hydrolase) (KYNU))

Andere Bezeichnung: KYNU/Kynureninase (KYNU Produkte)

Synonyme: BA2753 Protein, 4432411A05Rik Protein, Kynureninase Protein, kynureninase Protein, kynureninase (L-kynurenine hydrolase) Protein, kynu-1 Protein, kynU Protein, CNC03980 Protein, Mrub_2118 Protein, Ndas_0787 Protein, Trad_2365 Protein, Ftrac_2835 Protein, Celal_2292 Protein, Deima_1563 Protein, Celly_0597 Protein, Deipr_2230 Protein, Fluta_1605 Protein, Halhy_3696 Protein, Mesop_4277 Protein, KYNU Protein, Kynu Protein

Hintergrund:

Background: Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein which belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp120 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Synonym: KYNUU

Molekulargewicht: 53.7 kDa

UniProt: Q16719