Kallikrein 6 Protein (KLK6) (His tag)

Produktnummer ABIN7196666

Produktdetails

Target: Kallikrein 6 (KLK6)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Kallikrein 6 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Kallikrein 6/KLK6 Protein (His Tag)(Active)

Sequenz: Met 1-Lys 244

Produktmerkmale: A DNA sequence encoding the human KLK6 isoform 1 (Q92876-1) (Met 1-Lys 244), was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC, R&D Systems, Catalog # ES014.The specific activity is > 250 pmols/min/μg.(Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Kallikrein 6 (KLK6)

Andere Bezeichnung: Kallikrein 6/KLK6 (KLK6 Produkte)

Synonyme: Bssp Protein, Klk7 Protein, PRSS18 Protein, PRSS9 Protein, SP59 Protein, hK6 Protein, Prss9 Protein, AI849898 Protein, BSP Protein, Klk29 Protein, MSP Protein, Prss18 Protein, neurosin Protein, kallikrein related peptidase 6 Protein, kallikrein related-peptidase 6 Protein, kallikrein-6 Protein, KLK6 Protein, Klk6 Protein, LOC100716801 Protein

Hintergrund:

Background: KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Synonym: Kallikrein-6, Neurosin, Protease M, SP59, Serine Protease 18, Serine Protease 9, Zyme, KLK6, PRSS18, PRSS9

Molekulargewicht: 26.6 kDa

Pathways: Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling