IL15RA Protein (Fc Tag)

Produktnummer ABIN7320556

Produktdetails

Target: IL15RA (Interleukin 15 Receptor, alpha (IL15RA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses IL15RA Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse IL15RA/CD215 Protein (Fc Tag)(Active)

Sequenz: Gly33-Lys205

Produktmerkmale: Recombinant Mouse Interleukin-15 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Gly33-Lys205 is expressed with a Fc tag at the C-terminus.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 0.5-2 ng/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL15RA (Interleukin 15 Receptor, alpha (IL15RA))

Andere Bezeichnung: IL15RA/CD215 (IL15RA Produkte)

Synonyme: IL15RA Protein, CD215 Protein, AA690181 Protein, IL-15RA Protein, interleukin 15 receptor subunit alpha Protein, interleukin 15 receptor, alpha chain Protein, IL15RA Protein, Il15ra Protein

Hintergrund:

Background: Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45 % amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

Synonym: Interleukin-15 receptor subunit alpha,Il15ra,sIL-15 receptor subunit alpha

Molekulargewicht: 45.5 kDa

UniProt: Q60819

Pathways: JAK-STAT Signalweg