IL12RB2 Protein (His tag)

Produktnummer ABIN7320408

Produktdetails

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL12RB2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse IL12RB2/IL12R-beta 2 Protein (His Tag)(Active)

Sequenz: Met 1-Asn 637

Produktmerkmale: A DNA sequence encoding the mouse IL12RB2 (NP_032380.1) extracellular domain (Met 1-Asn 637) was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind Mouse IL12A & IL12B Heterodimer Protein in a functional ELISA.Immobilized mouse IL12RB2-His at 10 μg/ml (100 μl/well) can bind Mouse IL12A & IL12B Heterodimer Protein. The EC50 of Mouse IL12A & IL12B Heterodimer Protein is 50.2-117.2 ng/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Andere Bezeichnung: IL12RB2/IL12R-beta 2 (IL12RB2 Produkte)

Synonyme: IL12RB2 Protein, A930027I18Rik Protein, IL-12RB2 Protein, Ifnm Protein, interleukin 12 receptor subunit beta 2 Protein, interleukin 12 receptor, beta 2 Protein, IL12RB2 Protein, Il12rb2 Protein

Hintergrund:

Background: Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Synonym: IL12RB2, IL-12 receptor beta 2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12RB2, IL-12R-beta-2, interleukin-12 receptor beta-2 chain, interleukin-12 receptor subunit beta-2

Molekulargewicht: 70 kDa

NCBI Accession: NP_032380

Pathways: JAK-STAT Signalweg