IL1R2 Protein (His tag)

Produktnummer ABIN7196346

Produktdetails

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL1R2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse IL1R2/CD121b Protein (His Tag)(Active)

Sequenz: Met1-Glu355

Produktmerkmale: A DNA sequence encoding the mouse IL1R2 (P27931) (Met1-Glu355) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized mouse IL1R2-His at 10 μg/ml (100 μl/well) can bind biotinylated human IL1B-His , The EC50 of biotinylated human IL1B-His is 0.37-0.85 μg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Andere Bezeichnung: IL1R2/CD121b (IL1R2 Produkte)

Synonyme: CD121b Protein, CDw121b Protein, IL-1R-2 Protein, IL-1RT-2 Protein, IL-1RT2 Protein, IL1R2c Protein, IL1RB Protein, Il1r-2 Protein, IL-1R2 Protein, interleukin 1 receptor type 2 Protein, interleukin 1 receptor, type II Protein, interleukin-like Protein, IL1R2 Protein, Il1r2 Protein, KK34 Protein

Hintergrund:

Background: Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

Synonym: Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CD121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b

Molekulargewicht: 39.6 kDa

UniProt: P27931

Pathways: NF-kappaB Signalweg