FZD8 Protein (His tag)

Produktnummer ABIN7319870

Produktdetails

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses FZD8 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Frizzled-8 (C-6His)

Sequenz: Ala28-Pro172

Produktmerkmale: Recombinant Human Frizzled-8 is produced by our Mammalian expression system and the target gene encoding Ala28-Pro172 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Andere Bezeichnung: Frizzled-8 (FZD8 Produkte)

Synonyme: FZ-8 Protein, hFZ8 Protein, FZD8 Protein, Fz-8 Protein, frizzled8 Protein, xfz8 Protein, Xfz8 Protein, frizzled-8 Protein, hfz8 Protein, Fz8 Protein, fzd8 Protein, fz5 Protein, fz8a Protein, fzc Protein, wu:fd02c05 Protein, zg05 Protein, ZG06 Protein, Zfz8b Protein, fz6 Protein, fz8b Protein, fzA Protein, ik:tdsubc_1e1 Protein, xx:tdsubc_1e1 Protein, zfzA Protein, frizzled class receptor 8 Protein, frizzled class receptor 8 S homeolog Protein, frizzled class receptor 8 L homeolog Protein, frizzled class receptor 8a Protein, frizzled class receptor 8b Protein, FZD8 Protein, fzd8.S Protein, fzd8 Protein, Fzd8 Protein, fzd8.L Protein, fzd8a Protein, fzd8b Protein

Hintergrund:

Background: Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement, with low density lipoprotein receptor-related proteins LRP-5 or LRP-6 acting as co-receptors, stabilizes beta -catenin and promotes gene transcription that is important in development and tissue maintenance. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. These ligands bind the extracellular CRD of Frizzled-8, blocking Wnt binding. The recombinant Frizzled-8 CRD has also been used to block Wnt signaling and inhibit growth of teratocarcinomas.

Synonym: frizzled 8, frizzled family receptor 8, Frizzled8, Frizzled-8, FZ-8, FZD8, hFZ8

Molekulargewicht: 17.3 kDa

UniProt: Q9H461

Pathways: WNT Signalweg