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FLT1 Protein (His tag)

FLT1 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Produktnummer ABIN7195819
  • Target Alle FLT1 Proteine anzeigen
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 24
    • 3
    • 3
    • 3
    Ratte
    Quelle
    • 12
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FLT1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Rat VEGFR1/FLT-1 Protein (His Tag)(Active)
    Sequenz
    Met1-Glu758
    Produktmerkmale
    A DNA sequence encoding the rat FLT1 (P53767) (Met1-Glu758) was expressed with a polyhistidine tag at the C-terminus.
    Reinheit
    > 90 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA.Immobilized ratFLT1-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse VEGFD-Fc with a linear range of 0.125-2.0 μg/ml.
    Top Product
    Discover our top product FLT1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    Andere Bezeichnung
    VEGFR1/FLT-1 (FLT1 Produkte)
    Synonyme
    FLT Protein, FLT-1 Protein, VEGFR-1 Protein, VEGFR1 Protein, FLT1 Protein, flt1b Protein, sFlt1 Protein, AI323757 Protein, Flt-1 Protein, fms related tyrosine kinase 1 Protein, FMS-related tyrosine kinase 1 Protein, vascular endothelial growth factor receptor 1 Protein, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Protein, FMS-like tyrosine kinase 1 Protein, vascular endothelial growth factor receptor-1 Protein, FLT1 Protein, Flt1 Protein, CpipJ_CPIJ012087 Protein, flt1 Protein, FLT-1 Protein
    Hintergrund

    Background: Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains seven Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: FLT1;Flt-1;Vegfr1

    Molekulargewicht
    84 kDa
    UniProt
    P53767
    Pathways
    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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