EPH Receptor B1 Protein (EPHB1) (AA 564-984) (His tag)

Produktnummer ABIN7319623

Produktdetails

Target: EPH Receptor B1 (EPHB1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 564-984

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses EPH Receptor B1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human EphB1/EPHT2 Protein (aa 564-984, His Tag)(Active)

Sequenz: Ser564-Ala984

Produktmerkmale: Recombinant Human EphB1 is produced by our Mammalian expression system and the target gene encoding Ser564-Ala984 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human EphB1-His at 10μg/ml(100 μl/well) can bind Mouse EFNB2-Fc(Cat: PKSM041012). The ED50 of Human EphB1-His is 53.1 ug/ml .

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: EPH Receptor B1 (EPHB1)

Andere Bezeichnung: EphB1/EPHT2 (EPHB1 Produkte)

Synonyme: ELK Protein, EPHT2 Protein, Hek6 Protein, NET Protein, ephb1-a Protein, xek Protein, Xek Protein, MGC89790 Protein, EPHB1 Protein, CEK6 Protein, EK6 Protein, 9330129L11 Protein, AW488255 Protein, C130099E04Rik Protein, Cek6 Protein, ENSMUSG00000074119 Protein, Elk Protein, Elkh Protein, Net Protein, Ephb2 Protein, Erk Protein, elk Protein, EPH receptor B1 Protein, EPH receptor B1 S homeolog Protein, ephrin type-B receptor 1 Protein, Eph receptor B1 Protein, EPHB1 Protein, ephb1.S Protein, ephb1 Protein, LOC100467687 Protein, Ephb1 Protein

Hintergrund:

Background: Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. It binds to ephrin-B1, ephrin-B2 and ephrin-B3. EPHB1 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.

Synonym: Ephrin Type-B Receptor 1, ELK, EPH Tyrosine Kinase 2, EPH-Like Kinase 6, EK6, hEK6, Neuronally-Expressed EPH, Related Tyrosine Kinase, NET, Tyrosine-Protein Kinase Receptor EPH-2, EPHB1, ELK, EPHT2, HEK6

Molekulargewicht: 48.8 kDa

UniProt: P54762

Pathways: RTK Signalweg