Dual Specificity Phosphatase 3 (DUSP3) protein (His tag)

Produktnummer ABIN7319414

Produktdetails

Target: Dual Specificity Phosphatase 3 (DUSP3)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: His tag

Verwendungszweck: Recombinant Human DUSP3/VHR Protein (His Tag)

Sequenz: Ser2-Pro185

Produktmerkmale: Recombinant Human DUSP3 is produced by our E.coli expression system and the target gene encoding Ser2-Pro185 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: Dual Specificity Phosphatase 3 (DUSP3)

Andere Bezeichnung: DUSP3/VHR (DUSP3 Produkte)

Synonyme: dusp3 Protein, si:bz18k17.3 Protein, si:rp71-18k17.3 Protein, VHR Protein, RGD1560049 Protein, 2210015O03Rik Protein, 5031436O03Rik Protein, T-DSP11 Protein, dual specificity phosphatase 3 Protein, dual specificity phosphatase 3b Protein, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Protein, DUSP3 Protein, dusp3b Protein, Dusp3 Protein

Substanzklasse: Viral Protein

Hintergrund:

Background: Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.

Synonym: Dual specificity protein phosphatase 3,DUSP3,Dual specificity protein phosphatase VHR,Vaccinia H1-related phosphatase,VHR

Molekulargewicht: 22.6 kDa

UniProt: P51452

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades