DKK2 Protein (His tag,Fc Tag)

Produktnummer ABIN7318404

Produktdetails

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses DKK2 Protein ist gelabelt mit His tag,Fc Tag.

Verwendungszweck: Recombinant Human DKK2 Protein (His&Fc Tag)

Sequenz: Asp251-Ile526

Produktmerkmale: Recombinant Human Dickkopf-related protein 2 is produced by our Mammalian expression system and the target gene encoding Asp251-Ile526 is expressed with a Fc tag at the N-terminus, 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.2.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Andere Bezeichnung: DKK2 (DKK2 Produkte)

Synonyme: DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein

Hintergrund:

Background: Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Synonym: Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2

Molekulargewicht: 58.9 kDa

UniProt: Q9UBU2

Pathways: WNT Signalweg