CD131 Protein (His tag)

Produktnummer ABIN7317843

Produktdetails

Target: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD131 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CD131/CSF2RB Protein (His Tag)(Active)

Sequenz: Met 1-Trp 443

Produktmerkmale: A DNA sequence encoding the extracellular domain (Met 1-Trp 443) of human CSF2RB (NP_000386.1) expressed, fused with a polyhistidine-tag at the C-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind biotinylated human EPOR/Fc with a linear range of 0.16-4 μg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Andere Bezeichnung: CD131/CSF2RB (CSF2RB Produkte)

Synonyme: Csf2rb1 Protein, CSF2RB Protein, cd131 Protein, cdw131 Protein, il3rb Protein, il5rb Protein, il-3rbc Protein, CD131 Protein, CDw131 Protein, IL3RB Protein, IL5RB Protein, SMDP5 Protein, AI848964 Protein, AIC2B Protein, Bc Protein, Csfgmrb Protein, Il3r Protein, Il3rb Protein, Il3rb1 Protein, Il5rb Protein, colony stimulating factor 2 receptor beta common subunit Protein, colony stimulating factor 2 receptor beta common subunit S homeolog Protein, cytokine receptor common subunit beta-like Protein, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Protein, CSF2RB Protein, Csf2rb Protein, csf2rb.S Protein, CRCBL Protein, csf2rb Protein

Hintergrund:

Background: Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Synonym: CD131,CDw131,IL3RB,IL5RB,SMDP5

Molekulargewicht: 50 kDa

NCBI Accession: NP_000386

Pathways: JAK-STAT Signalweg