COLEC12 Protein (His tag)

Produktnummer ABIN7195183

Produktdetails

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses COLEC12 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat CLP1/COLEC12 Protein (His Tag)

Sequenz: Ala101-Leu742

Produktmerkmale: A DNA sequence encoding the mature form of rat COLEC12 (Q4V885) (Ala101-Leu742) was expressed,with a polyhistide tag at the N-terminus.

Reinheit: > 99 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: COLEC12 (Collectin Sub-Family Member 12 (COLEC12))

Andere Bezeichnung: CLP1/COLEC12 (COLEC12 Produkte)

Synonyme: COLEC12 Protein, CLP1 Protein, NSR2 Protein, SCARA4 Protein, SRCL Protein, CL-P1 Protein, Scara4 Protein, hm:zeh0853 Protein, id:ibd2826 Protein, sb:cb377 Protein, si:ch211-212m21.5 Protein, collectin subfamily member 12 Protein, collectin sub-family member 12 Protein, COLEC12 Protein, colec12 Protein, Colec12 Protein

Hintergrund:

Background: CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.

Synonym: Clp1,Nsr2,COLEC12

Molekulargewicht: 72.4 kDa

UniProt: Q4V885

Pathways: Activation of Innate immune Response