F13A1 Protein (His tag)

Produktnummer ABIN7319648

Produktdetails

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses F13A1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human F13a/Factor XIIIa Protein (His Tag)

Sequenz: Gly39-Met732

Produktmerkmale: Recombinant Human Coagulation Factor XIII A Chain is produced by our Mammalian expression system and the target gene encoding Gly39-Met732 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5 % Sucrose, 1 % Tween 20 (v/v),0.3 % Histidine (w/v), pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Andere Bezeichnung: F13a/Factor XIIIa (F13A1 Produkte)

Synonyme: F13a Protein, f13a1 Protein, wu:fo83d04 Protein, zgc:153334 Protein, F13A1 Protein, F13A Protein, 1200014I03Rik Protein, AI462306 Protein, coagulation factor XIII A1 chain Protein, coagulation factor XIII, A1 polypeptide b Protein, coagulation factor XIII A chain Protein, coagulation factor XIII, A1 subunit Protein, F13a1 Protein, f13a1b Protein, F13A1 Protein

Hintergrund:

Background: Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Synonym: Coagulation Factor XIII A Chain, Coagulation Factor XIIIa, Protein-Glutamine Gamma-Glutamyltransferase A Chain, Transglutaminase A Chain, F13A1, F13A

Molekulargewicht: 80.3 kDa

UniProt: P00488