Caspase 7 Protein (His tag)

Produktnummer ABIN7194660

Produktdetails

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Caspase 7 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CASP7/caspase 7 Protein (His Tag)

Sequenz: Met 1-Gln 303

Produktmerkmale: A DNA sequence encoding the human CASP7 (P55210-1) (Met 1-Gln 303) was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM HEPES, 100 mM NaCl, 1 mM EDTA, 0.10 % Sucrose, 0.1 % chaps, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Andere Bezeichnung: CASP7/caspase 7 (CASP7 Produkte)

Synonyme: xCaspase-7 Protein, caspase-7 Protein, caspase7 Protein, cmh-1 Protein, ice-lap3 Protein, mch3 Protein, CASP7 Protein, AI314680 Protein, CMH-1 Protein, ICE-IAP3 Protein, Mch3 Protein, mCASP-7 Protein, CASP-7 Protein, ICE-LAP3 Protein, LICE2 Protein, MCH3 Protein, Caspase-7 Protein, MCH3/SCA-2 Protein, SCA-2 Protein, caspase 7 Protein, caspase-7 Protein, caspase 7 S homeolog Protein, CASP7 Protein, xcaspase-7 Protein, casp7 Protein, casp7.S Protein, Casp7 Protein

Hintergrund:

Background: Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.

Synonym: CASP-7,CMH-1,ICE-LAP3,LICE2,MCH3

Molekulargewicht: 35kDa

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity