Casein Kinase 1 gamma 2 Protein (His tag)

Produktnummer ABIN7317052

Produktdetails

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses Casein Kinase 1 gamma 2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CSNK1G2 Protein (His Tag)(Active)

Sequenz: Met 18-Lys 415

Produktmerkmale: A DNA sequence encoding the mature form of human CSNK1G2 (P78368-1) (Met 18-Lys 415) was expressed, with a polyhistidine tag at the N-terminus.

Reinheit: > 80 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 13 nmol/min/mg using casein as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, 1 mM DTT, pH 8.0

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Andere Bezeichnung: CSNK1G2 (CSNK1G2 Produkte)

Synonyme: CK1g2 Protein, 2810429I12Rik Protein, AI463719 Protein, CKI Protein, ck1-gamma Protein, CSNK1G2 Protein, ck1g2 Protein, csnk1g2 Protein, fj97g11 Protein, wu:fj97g11 Protein, wz8345 Protein, zgc:110719 Protein, zgc:153415 Protein, casein kinase 1 gamma 2 Protein, casein kinase 1, gamma 2 Protein, casein kinase 1 gamma 2 L homeolog Protein, casein kinase 1, gamma 2a Protein, casein kinase 1, gamma 2b Protein, CSNK1G2 Protein, Csnk1g2 Protein, csnk1g2.L Protein, csnk1g2 Protein, csnk1g2a Protein, csnk1g2b Protein

Hintergrund:

Background: Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exception of gamma, increase the phosphorylation of Dsh in vivo. Casein kinase 1 gamma (CK1gamma, or CSNK1G) is associated with the cell membrane and binds to LRP. CK1gamma was found to be needed for Wnt signaling through Wnt receptor LRP. CSNK1G2 inhibits Smad3-mediated TGF-beta responses including induction of target genes and cell growth arrest, and this inhibition is dependent on CSNK1G2 kinase activity. The overexpression of CSNK1G2 in human cancers, may act as an oncoprotein during tumorigenesis. In addition, as an MTA1s-binding protein, CSNK1G2 could further potentiate the estrogen receptor (ER) corepressive function of MTA1s.

Synonym: Casein kinase I isoform gamma-2, CK1G2, CSNK1G2

Molekulargewicht: 47.8 kDa

Pathways: Hedgehog Signalweg