AOC3 Protein (Fc Tag)

Produktnummer ABIN7319524

Produktdetails

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses AOC3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human VAP-1/AOC3 Protein (Fc Tag)

Sequenz: Arg28-Asn763

Produktmerkmale: Recombinant Human Membrane primary amine oxidase is produced by our Mammalian expression system and the target gene encoding Arg28-Asn763 is expressed with a Fc tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,500 mM NaCl, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Andere Bezeichnung: VAP-1/AOC3 (AOC3 Produkte)

Synonyme: HPAO Protein, SSAO Protein, VAP-1 Protein, VAP1 Protein, aoc2 Protein, BOLAO Protein, amine oxidase, copper containing 3 Protein, amine oxidase, copper containing 3 L homeolog Protein, AOC3 Protein, aoc3.L Protein, Aoc3 Protein

Hintergrund:

Background: Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflammation. This rise in metabolic products contributes to generating advanced glycation end-products and oxidative stress along with the monoamine detoxification in the organism. It is highly expressed on the endothelium of the lung and trachea, and absent from leukocytes and epithelial cells. Membrane-bound VAP-1 releases an active, soluble form of the protein, which may be conducive to increased inflammation and the progression of many vascular disorders. In particular, elevation of VAP-1 activity and the increased enzymatic-mediated deamination is proposed to play a role in renal and vascular disease, oxidative stress, acute and chronic hyperglycemia, and diabetes complications.

Synonym: Membrane primary amine oxidase, Copper amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1, AOC3, VAP-1, SSAO, HPAO,VAP1

Molekulargewicht: 108.5 kDa

UniProt: Q16853

Pathways: Feeding Behaviour