AOC3 Protein (AA 27-763)

Produktnummer ABIN2667600

Produktdetails

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 27-763

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Multiplex Assay (MA)

Reinheit: >98 % , as determined by Coomassie stained SDS-PAGE.

Endotoxin-Niveau:

Less than 0.1 ng per μg of protein.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Biological activity: Human VAP-1 is able to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is > 16 pMoles/min/μg of VAP-1.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.

Buffer: Lyophilized

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Unopened vial can be stored at -20°C or -70°C.

Antigendetails

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Andere Bezeichnung: VAP-1 (AOC3 Produkte)

Synonyme: HPAO Protein, SSAO Protein, VAP-1 Protein, VAP1 Protein, aoc2 Protein, BOLAO Protein, amine oxidase, copper containing 3 Protein, amine oxidase, copper containing 3 L homeolog Protein, AOC3 Protein, aoc3.L Protein, Aoc3 Protein

Hintergrund: VAP-1 is a type II cell adhesion membrane protein belonging to the copper/topaquinone oxidase family. Functionally, VAP-1 is a nonclassical inflammation-inducible endothelial molecule involved in leukocyte-subtype-specific rolling under physiological shear. Molecularly, VAP-1 belongs to a special class of cell surface amino oxidases. The enzymatic reaction itself and the biologically active end products can potentially regulate the adhesive status of the vessel wall. Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. This protein is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases.

Molekulargewicht: The 737 amino acid recombinant protein has a predicted molecular mass of approximately 84 kDa. Recombinant VAP-1 is a mixture of monomers and disulfide linked homodimers. The predicted N-terminal amino acid is Gly.

Pathways: Feeding Behaviour