ACVR1 Protein (His tag)

Produktnummer ABIN7318127

Produktdetails

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses ACVR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human ALK-2/ACVR1 Protein (Human Cells, His Tag)

Sequenz: Met21-Val124

Produktmerkmale: Recombinant Human Activin Receptor Type-1A is produced by our Mammalian expression system and the target gene encoding Met21-Val124 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Andere Bezeichnung: ALK-2/ACVR1 (ACRV1 Produkte)

Synonyme: ACTRI Protein, ACVR1A Protein, ACVRLK2 Protein, ALK2 Protein, FOP Protein, SKR1 Protein, TSRI Protein, ActR-IA Protein, ActR-I Protein, ActRIA Protein, Acvr Protein, Acvrlk2 Protein, Alk-2 Protein, Alk8 Protein, D330013D15Rik Protein, Tsk7L Protein, actri Protein, acvr1 Protein, acvr1-a Protein, acvr1-b Protein, acvr1a Protein, acvrlk2 Protein, alk-2 Protein, alk2 Protein, alk8 Protein, fop Protein, sax Protein, skr1 Protein, tsri Protein, xALK-2 Protein, activin A receptor type 1 Protein, activin A receptor, type 1 Protein, activin A receptor type 1 S homeolog Protein, ACVR1 Protein, Acvr1 Protein, acvr1.S Protein

Hintergrund:

Background: Activin receptor type-1, also known as Activin receptor type I, Activin receptor-like kinase 2, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, ACVRLK2 and ACVR1, is a single-pass type I membrane protein. ACVR1 is expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. ACVR1 belongs to the protein kinase superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 signals a particular transcriptional response in concert with activin type II receptors.

Synonym: Activin Receptor Type-1, Activin Receptor Type I, ACTR-I, Activin Receptor-Like Kinase 2, ALK-2, Serine/Threonine-Protein Kinase Receptor R1, SKR1, TGF-B Superfamily Receptor Type I, TSR-I, ACVR1, ACVRLK2,ACVR1A,ACVRLK2,ALK2,FOP,SKR1

Molekulargewicht: 12.6 kDa

UniProt: Q04771