SLAMF8 Protein (AA 23-233) (His tag,AVI tag,Biotin)

Produktnummer ABIN6972956

Produktdetails

Target: SLAMF8 (SLAM Family Member 8 (SLAMF8))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 23-233

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SLAMF8 Protein ist gelabelt mit His tag,AVI tag,Biotin.

Spezifität: Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Produktmerkmale: Biotinylated Human BLAME / SLAMF8 Protein, His,Avitag™

Reinheit: >85 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Kommentare:

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Sodium Citrate, 150 mM NaCl, pH 5.5

Lagerung: -20 °C

Antigendetails

Target: SLAMF8 (SLAM Family Member 8 (SLAMF8))

Andere Bezeichnung: BLAME (SLAMF8 Produkte)

Synonyme: BLAME Protein, CD353 Protein, SBBI42 Protein, 5830408F06Rik Protein, Blame Protein, SLAM family member 8 Protein, Slamf8 Protein, slamf8 Protein, SLAMF8 Protein

Hintergrund: BLAME (B-lymphocyte activator macrophage expressed) is also known as SLAM family member 8(SLAMF8), CD353. BLAME is a cell surface receptor that is expressed upon activation of macrophages (Ms) by IFN-γ or bacteria, is a negative regulator of ROS in response to Gram+ and Gram- bacteria. May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. SLAMF8 is a costimulatory molecule that affects the activation of macrophages in inflammation and in immunosuppression and inflammation response to glioma cells could aid immunotherapy for glioma.

Molekulargewicht: 27.1 kDa

NCBI Accession: NP_064510