Calreticulin Protein (CALR) (His tag)

Produktnummer ABIN6964232

Produktdetails

Target: Calreticulin (CALR)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Calreticulin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human CALR protein with C-terminal 6xHis tag

Spezifität: CALR (Glu18-Leu417) 6xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Calreticulin (CALR)

Andere Bezeichnung: CALR (CALR Produkte)

Synonyme: CRT Protein, RO Protein, SSA Protein, cC1qR Protein, crc Protein, crt Protein, Calregulin Protein, CG9429 Protein, Clr Protein, Dmel\\CG9429 Protein, anon-EST:Liang-2.11 Protein, anon-EST:Liang-2.17 Protein, anon-EST:fe3D7 Protein, clone 2.11 Protein, clone 2.17 Protein, eth Protein, potp Protein, cc1qr Protein, ssa Protein, NV19007 Protein, CRP55 Protein, ERp60 Protein, HACBP Protein, CHOT1 Protein, CHT1 Protein, CT1 Protein, AA589632 Protein, CRTR Protein, Creat Protein, CCDS1 Protein, calrl2 Protein, fc66d10 Protein, wu:fc66d10 Protein, wu:fj50c03 Protein, zgc:66153 Protein, calreticulin Protein, calreticulin L homeolog Protein, Calreticulin Protein, putative calreticulin Protein, solute carrier family 6 member 8 Protein, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Protein, CALR Protein, calr.L Protein, Crt Protein, crt Protein, CRT Protein, Calr Protein, calr Protein, LMJF_31_2600 Protein, Crc Protein, Slc6a8 Protein, SLC6A8 Protein, LOC8269812 Protein

Hintergrund: Synonymes: cC1qR, CRT, HEL-S-99n, RO, SSA
Description: Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]

Molekulargewicht: predicted molecular mass of 47.3 kDa after removal of the signal peptide.The apparent molecular mass of CALR-His is 55-70 kDa due to glycosylation.

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response