MUC1 Protein (His tag)

Produktnummer ABIN6964084

Produktdetails

Target: MUC1 (Mucin 1 (MUC1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MUC1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human MUC1 Protein with C-terminal 6xHis tag

Spezifität: MUC1 (Leu1036-Val1156) 6xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC1 (MUC1 Produkte)

Synonyme: CA 15-3 Protein, CD227 Protein, EMA Protein, H23AG Protein, KL-6 Protein, MAM6 Protein, MCKD1 Protein, MUC-1 Protein, MUC-1/SEC Protein, MUC-1/X Protein, MUC1/ZD Protein, PEM Protein, PEMT Protein, PUM Protein, Muc-1 Protein, mucin 1, cell surface associated Protein, mucin 1, transmembrane Protein, MUC1 Protein, Muc1 Protein

Hintergrund: Synonymes: ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM
Description: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Molekulargewicht: predicted molecular mass of 14.4 kDa after removal of the signal peptide.

Gen-ID: 4582

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling