TNF alpha Protein (AA 77-233) (His tag)
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- Target Alle TNF alpha Proteine anzeigen
- TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 77-233
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses TNF alpha Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant human TNFa protein with C-terminal 6xHis tag
- Spezifität
- TNFa (Val77-Leu233) 6xHis tag
- Produktmerkmale
- Extracellular Domain Protein
- Aufreinigung
- Purified from cell culture supernatant by affinity chromatography
- Reinheit
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product TNF alpha Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Haltbarkeit
- 12 months
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- Target
- TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
- Andere Bezeichnung
- TNFA (TNF alpha Produkte)
- Hintergrund
- This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
- Molekulargewicht
- predicted molecular mass of 18.1 kDa after removal of the signal peptide.
- Gen-ID
- 7124
- UniProt
- P01375
- Pathways
- NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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