Cynomolgus ACE2, His Tag is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Thr 741 (Accession # A0A2K5X283-1). Predicted N-terminus: His This protein carries a polyhistidine tag at the N-terminus.
ACE2
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ELISA
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, Arginine, pH 7.5
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-80 °C
Informationen zur Lagerung
This product is stable after storage at: The product MUST be stored at -70°C or lower upon receipt, -70°C for 3 months under sterile conditions.
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Hintergrund
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.