DUSP10 Protein (AA 149-482) (His tag)

Produktnummer ABIN668018

Produktdetails

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Protein-Typ: Recombinant

Proteineigenschaft: AA 149-482

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses DUSP10 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: DUSP10, 149-482aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 50% glycerol, 200mM NaCl

Lagerung: 4 °C

Antigendetails

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Andere Bezeichnung: DUSP10 (DUSP10 Produkte)

Synonyme: DUSP10 Protein, MKP-5 Protein, MKP5 Protein, 2610306G15Rik Protein, AI158871 Protein, Mkp-5 Protein, Mkp5 Protein, dual specificity phosphatase 10 Protein, DUSP10 Protein, Dusp10 Protein

Hintergrund: DUSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases(DUSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DUSP10 has been shown to interact with MAPK14 and MAPK8. When expressed in mammalian cells, DUSP10 blocks the enzymatic activation of MAP kinases with the selectivity p38 approximately JNK/SAPK >> ERK. Recombinant human DUSP10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Dual specificity protein phosphatase 10, MKP-5, MKP5. NCBI no.: NP_009138

Molekulargewicht: 40.4kDa (359aa), confirmed by MALDI-TOF