DCK Protein (AA 1-260) (His tag)

Produktnummer ABIN667827

Produktdetails

Target: DCK (Deoxycytidine Kinase (DCK))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-260

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses DCK Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: DCK, 1-260aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 0.1 mM PMSF, 2mM EDTA, 10% Glycerol

Lagerung: 4 °C

Antigendetails

Target: DCK (Deoxycytidine Kinase (DCK))

Andere Bezeichnung: DCK (DCK Produkte)

Synonyme: dck Protein, DCK Protein, wu:fc15f06 Protein, zgc:101771 Protein, dck1 Protein, deoxycytidine kinase Protein, deoxycytidine kinase, gene 2 L homeolog Protein, deoxycytidine kinase, gene 2 Protein, Deoxycytidine kinase Protein, deoxycytidine kinase, gene 1 L homeolog Protein, DCK Protein, dck Protein, dck.2.L Protein, dck.2 Protein, Dck Protein, FPV059 Protein, FPV151 Protein, dck.1.L Protein

Hintergrund: DCK is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. This protein is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. Recombinant human DCK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: MGC117410, MGC138632, Deoxycytidine kinase. NCBI no.: NP_000779

Molekulargewicht: 34.6 kDa(296aa), confirmed by MALDI-TOF