KPNA2 Protein (AA 1-529) (His tag)

Produktnummer ABIN667661

Produktdetails

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-529

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses KPNA2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: KPNA2, 1-529aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT

Lagerung: 4 °C

Antigendetails

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Andere Bezeichnung: KPNA2 (KPNA2 Produkte)

Synonyme: IPOA1 Protein, QIP2 Protein, RCH1 Protein, SRP1alpha Protein, ima2 Protein, importin Protein, 2410044B12Rik Protein, PTAC58 Protein, Rch1 Protein, ipoa1 Protein, kpna2 Protein, qip2 Protein, rch1 Protein, srp1alpha Protein, hm:zeh0389 Protein, hm:zeh0389r Protein, zgc:113902 Protein, zgc:86945 Protein, karyopherin subunit alpha 2 Protein, importin subunit alpha-2 Protein, Importin subunit alpha-2 Protein, karyopherin (importin) alpha 2 Protein, karyopherin alpha-2 subunit like L homeolog Protein, karyopherin alpha 2 (RAG cohort 1, importin alpha 1) Protein, KPNA2 Protein, EDI_246290 Protein, EDI_335040 Protein, ima2 Protein, Kpna2 Protein, kpna2.L Protein, kpna2 Protein

Hintergrund: Karyopherin alpha2 (KPNA2) is a member of the karyopherin alpha family. This protein plays a key role in the nuclear import of proteins with a classical nuclear localization signal (NLS). KPNA2 bound in vitro specifically and directly to substrates containing either a simple or bipartite NLS motif. It promoted docking of import substrates to the nuclear envelope and together with recombinant human Ran reconstituted complete nuclear protein import. Recombinant human KPNA2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Importin subunit alpha-2, IPOA1, QIP2, SRP1alpha. NCBI no.: AAH05978

Molekulargewicht: 60.5 kDa (553aa)

Pathways: M Phase, Protein targeting to Nucleus