CDKN2C Protein (AA 1-168) (His tag)

Produktnummer ABIN667655

Produktdetails

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-168

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CDKN2C Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: CDKN2C, 1-168aa, Human, His tag, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl

Lagerung: 4 °C

Antigendetails

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Andere Bezeichnung: CDKN2C (CDKN2C Produkte)

Synonyme: CDKN2C Protein, p18 Protein, ink4c Protein, p18-ink4c Protein, INK4C Protein, p18-INK4C Protein, C77269 Protein, INK4c Protein, INK4d Protein, p18INK4c Protein, cyclin dependent kinase inhibitor 2C Protein, cyclin-dependent kinase inhibitor 2C Protein, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Protein, CDKN2C Protein, cdkn2c Protein, Cdkn2c Protein

Hintergrund: CDKN2C (Cyclin-dependent kinase 4 inhibitor C ) belongs to the CDKN2 cyclin-dependent kinase inhibitor family. It has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. And this protein suppresses the cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Recombinant human CDKN2C protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Cyclin-dependent kinase 4 inhibitor C, INK4C, p18, p18-INK4C. NCBI no.: NP_001253

Molekulargewicht: 20.7kDa (192aa), confirmed by MALDI-TOF

Pathways: Zellzyklus, Mitotic G1-G1/S Phases