Deoxyuridine Triphosphatase (DUT) (AA 70-252) protein (His tag)

Produktnummer ABIN667220

Produktdetails

Target: Deoxyuridine Triphosphatase (DUT)

Protein-Typ: Recombinant

Proteineigenschaft: AA 70-252

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: His tag

Applikation: SDS-PAGE (SDS)

Produktmerkmale: DUT, 70-252aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS – PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.

Lagerung: 4 °C

Antigendetails

Target: Deoxyuridine Triphosphatase (DUT)

Andere Bezeichnung: DUT (DUT Produkte)

Synonyme: BcDNA:LD08534 Protein, CG4584 Protein, Dmel\\CG4584 Protein, LD08534 Protein, UTPase Protein, anon-SAGE:Wang-077 Protein, dUTPase Protein, Tb07.27E10.390 Protein, dutpase Protein, 5031412I06Rik Protein, 5133400F09Rik Protein, D2Bwg0749e Protein, Dutp Protein, PIP4 Protein, deoxyuridine triphosphatase Protein, Deoxyuridine triphosphatase Protein, dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 Protein, involved in nucleotide metabolism Protein, tegument protein Protein, dUTPase Protein, deoxyuridine triphosphatase L homeolog Protein, DUT Protein, dUTPase Protein, P18 Protein, AlHV1gp51 Protein, UL50 Protein, HVT058 Protein, ORF9 Protein, ORF8 Protein, U45 Protein, GAMMAHV.ORF54 Protein, Tc00.1047053509151.130 Protein, Tc00.1047053508175.160 Protein, Tb927.7.5160 Protein, dut.L Protein, Dut Protein

Substanzklasse: Viral Protein

Hintergrund: DUT, also known as dUTP pyrophosphatase, is a ubiquitous enzyme that functions in nucleotide metabolism. This protein, in the presence of magnesium ions, is responsible for hydrolyzing dUTP to dUMP and diphosphate. This reaction is important for keeping the intracellular dUTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that DUT is essential for cell viability, further implying that it is a potential target for anticancer therapy. Recombinant human DUT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: dUTPase, dUTP pyrophosphatase, FLJ20622, dUTPase, dUTP pyrophosphatase, FLJ20622. NCBI no.: NP_001020419

Molekulargewicht: 21.6 kDa (204aa), confirmed by MALDI-TOF