Deoxyuridine Triphosphatase Produkte
(Deoxyuridine Triphosphatase (DUT))
Kategorien
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
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Ausgewählte Deoxyuridine Triphosphatase Kategorien
Deoxyuridine Triphosphatase Antikörper
High quality antibodies with extensive validation data.
Deoxyuridine Triphosphatase ELISA Kits
Reliable ELISA kits for a wide range of species.
Deoxyuridine Triphosphatase Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Deoxyuridine Triphosphatase Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), IF
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN560672
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7260715
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7266736
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Deoxyuridine Triphosphatase ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966332
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1129512
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Deoxyuridine Triphosphatase Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122640
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122639
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1352151
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Deoxyuridine Triphosphatase Produkten
: "The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis." in: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2332-42, (2015) (PubMed).: "Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme." in: The Journal of biological chemistry, Vol. 282, Issue 46, pp. 33572-82, (2007) (PubMed).
: "Modulation of human dUTPase using small interfering RNA." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 306-10, (2005) (PubMed).
: "The role of dUTPase and uracil-DNA repair in cancer chemotherapy." in: Current protein & peptide science, Vol. 2, Issue 4, pp. 361-70, (2002) (PubMed).
Synonyme und alternative Namen zu Deoxyuridine Triphosphatase
deoxyuridine triphosphatase (DUT), Deoxyuridine triphosphatase (dUTPase), deoxyuridine triphosphatase (P18), dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51), deoxyuridine triphosphatase (UL50), deoxyuridine triphosphatase (HVT058), involved in nucleotide metabolism (UL50), deoxyuridine triphosphatase (ORF9), deoxyuridine triphosphatase (ORF8), tegument protein (U45), dUTPase (GAMMAHV.ORF54), deoxyuridine triphosphatase (Tc00.1047053509151.130), deoxyuridine triphosphatase (Tc00.1047053508175.160), deoxyuridine triphosphatase (Tb927.7.5160), deoxyuridine triphosphatase L homeolog (dut.L), deoxyuridine triphosphatase (Dut), 5031412I06Rik, 5133400F09Rik, anon-SAGE:Wang-077, BcDNA:LD08534, CG4584, D2Bwg0749e, Dmel\\CG4584, Dutp, dUTPase, dutpase, LD08534, PIP4, Tb07.27E10.390, UTPaseBezeichner auf Proteinebene für Deoxyuridine Triphosphatase
- dUTP pyrophosphatase
- CG4584-PA
- CG4584-PB
- CG4584-PC
- CG4584-PD
- anon-SAGE:Wang-077
- dUTPase-PA
- dUTPase-PB
- dUTPase-PC
- dUTPase-PD
- deoxyuridine triphosphatase
- deoxyuridine 5'-triphosphate nucleotidohydrolase
- deoxyuridine triphosphatase, dUTPase, P18
- dUTP nucleotidohydrolase
- deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- PPAR-interacting protein 4
- dUTPase
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