PDPK1 Protein (AA 29-436) (His tag)

Produktnummer ABIN666881

Produktdetails

Target: PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 29-436

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PDPK1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: PDK1, 29-436aa, Human, His-tagged, Recombinant, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH 7.0) containing 100mM NaCl, 0.5mM DTT, 0.1mM EDTA, 0.1mM PMSF, 1mM MgCl2, 40% glycerol

Lagerung: 4 °C

Antigendetails

Target: PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))

Andere Bezeichnung: PDK1 (PDPK1 Produkte)

Synonyme: pdpk1 Protein, MGC82080 Protein, PDK1 Protein, PDPK2 Protein, PRO0461 Protein, Pdk1 Protein, zgc:153787 Protein, 3'-phosphoinositide-dependent protein kinase 1 Protein, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 Protein, ATPDK1 Protein, AtPDK1 Protein, T32M21.110 Protein, T32M21_110 Protein, zgc:77318 Protein, 3-phosphoinositide dependent protein kinase 1 Protein, 3-phosphoinositide dependent protein kinase 1 L homeolog Protein, 3-phosphoinositide dependent protein kinase-1 Protein, 3-phosphoinositide dependent protein kinase 1a Protein, 3-phosphoinositide-dependent protein kinase 1 Protein, 3'-phosphoinositide-dependent protein kinase 1 Protein, 3-phosphoinositide dependent protein kinase 1b Protein, PDPK1 Protein, pdpk1.L Protein, pdpk1 Protein, Pdpk1 Protein, pdpk1a Protein, LOC100380750 Protein, pdk-1 Protein, PDK1 Protein, pdpk1b Protein

Hintergrund: PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Pyruvate dehydrogenase kinase, isozyme 1, Pyruvate dehydrogenase kinase, isozyme 1 HGNC:8809, Mitochondrial pyruvate dehydrogenase kinase isoenzyme1, PDK1, Pyruvate dehydrogenase kinase isoform 1, Pyruvate dehydrogenase kinase, isoenzyme 1. NCBI no.: NP_002601

Molekulargewicht: 48.6 kDa (429 aa)

Pathways: PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals