CSF2RA Protein (AA 20-320) (His tag)

Produktnummer ABIN5855034

Produktdetails

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 20-320

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses CSF2RA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ADPLIPEKSD LRTVAPASSL NVRFDSRTMN LSWDCQENTT FSKCFLTDKK NRVVEPRLSN NECSCTFREI CLHEGVTFEV HVNTSQRGFQ QKLLYPNSGR EGTAAQNFSC FIYNADLMNC TWARGPTAPR DVQYFLYIRN SKRRREIRCP YYIQDSGTHV GCHLDNLSGL TSRNYFLVNG TSREIGIQFF DSLLDTKKIE RFNPPSNVTV RCNTTHCLVR WKQPRTYQKL SYLDFQYQLD VHRKNTQPGT ENLLINVSGD LENRYNFPSS EPRAKHSVKI RAADVRILNW SSWSEAIEFG SDDGHHHHHH

Reinheit: > 90 % by SDS - PAGE

Endotoxin-Niveau: < 1.0 EU per 1ug of protein (determined by LAL method)

Biological Activity Comment: Measured by its ability to inhibit GM-CSF dependent proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is less or equal to 10ug/ml in the presence of 0.5ng/ml GM-CSF.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Bioactivity Validated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Andere Bezeichnung: CSF2RA (CSF2RA Produkte)

Synonyme: CD116 Protein, CDw116 Protein, CSF2R Protein, CSF2RAX Protein, CSF2RAY Protein, CSF2RX Protein, CSF2RY Protein, GM-CSF-R-alpha Protein, GMCSFR Protein, GMR Protein, SMDP4 Protein, Csfgmra Protein, GM-CSF-Ra Protein, GM-CSFR Protein, colony stimulating factor 2 receptor, alpha Protein, colony stimulating factor 2 receptor alpha subunit Protein, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) Protein, CSF2RA Protein, Csf2ra Protein

Hintergrund: CSF2RA, also known as granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g, is a well-known hemopoietic growth factor that is used in the clinic to correct neutropaenia, usually as a result of chemotherapy. It is a key regulatory molecule causative of this aortopathy, and modulation of this cytokine might be an exploitable treatment strategy for the condition. It transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Recombinant human CSF2RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molekulargewicht: 35.9kDa (310aa) 40-57kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_001155003

UniProt: P15509

Pathways: JAK-STAT Signalweg