Thrombospondin 1 Protein (THBS1) (AA 19-1170) (Fc Tag)

Produktnummer ABIN6253308

Produktdetails

Target: Thrombospondin 1 (THBS1)

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-1170

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Thrombospondin 1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Thrombospondin-1 (human):Fc (human) (rec.)

Spezifität: The extracellular domain of human thrombospondin-1 (aa 19-1170) is fused to the N-terminus of the Fc region of human IgG1.

Produktmerkmale: Protein. The extracellular domain of human thrombospondin-1 (aa 19-1170) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin: <0.06EU/μg. Lyophilized from 0.2μm-filtered solution in PBS. Thrombospondin-1 (TSP1) is a 150-180  kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the thrombospondin family, TSP-2 is also homotrimeric, while TSP-3, -4, and -5/COMP are homopentameric. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal laminin G-like globular domain, an extended central region with one VWFC domain, 3 TSP type-1 domains, 2 EGF-like domains, and 8 TSP type-3 domains and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive and anti-thrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGFR-2 signaling on vascular endothelial cells (EC) and destabilizes adhesive contacts between EC. TSP-1's actions on vascular smooth muscle cells support arterial tone and blood pressure in the presence of vasodilatory stimulation. It is released from activated platelets and enhances platelet aggregation and adhesion. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP). TSP-1 dampens adaptive immune responses by inducing the differentiation of regulatory T cells and inhibiting TCR signaling. In the nervous system, it promotes excitatory synapse formation and supports the integration of neural progenitor cells into the olfactory bulb. In addition, TSP-1 is released by apoptotic cells and promotes macrophage-mediated debris clearance.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <0.06EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: Thrombospondin 1 (THBS1)

Andere Bezeichnung: Thrombospondin-1 (THBS1 Produkte)

Synonyme: THBS Protein, THBS-1 Protein, TSP Protein, TSP-1 Protein, TSP1 Protein, Thbs-1 Protein, tbsp1 Protein, thrombospondin-1 Protein, thbs Protein, thbs-1 Protein, tsp Protein, tsp-1 Protein, tsp1 Protein, Tsp1 Protein, THBS1 Protein, Tsp-1 Protein, wu:fc48c03 Protein, si:dkey-11e23.1 Protein, tsp2 Protein, thrombospondin 1 Protein, thrombospondin 1 S homeolog Protein, thrombospondin 1b Protein, thrombospondin 2 L homeolog Protein, THBS1 Protein, Thbs1 Protein, thbs1.S Protein, thbs1b Protein, thbs1 Protein, thbs2.L Protein

Hintergrund:

Alternate Names/Synonyms: TSP1

Product Description: Thrombospondin-1 (TSP1) is a 150-180  kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the thrombospondin family, TSP-2 is also homotrimeric, while TSP-3, -4, and -5/COMP are homopentameric. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal laminin G-like globular domain, an extended central region with one VWFC domain, 3 TSP type-1 domains, 2 EGF-like domains, and 8 TSP type-3 domains and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive and anti-thrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGFR-2 signaling on vascular endothelial cells (EC) and destabilizes adhesive contacts between EC. TSP-1's actions on vascular smooth muscle cells support arterial tone and blood pressure in the presence of vasodilatory stimulation. It is released from activated platelets and enhances platelet aggregation and adhesion. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP). TSP-1 dampens adaptive immune responses by inducing the differentiation of regulatory T cells and inhibiting TCR signaling. In the nervous system, it promotes excitatory synapse formation and supports the integration of neural progenitor cells into the olfactory bulb. In addition, TSP-1 is released by apoptotic cells and promotes macrophage-mediated debris clearance.

NCBI Accession: NP_003237

Pathways: Autophagie