ccp Protein, caca Protein, cca3 Protein, cryg4 Protein, cry-g-d Protein, MGC85594 Protein, CRYGD Protein, CACA Protein, CCA3 Protein, CCP Protein, CRYG4 Protein, CTRCT4 Protein, PCC Protein, cry-g-D Protein, Aey4 Protein, Cryg-1 Protein, DGcry-1 Protein, Lop12 Protein, Cryg4 Protein, Len Protein, crystallin gamma D L homeolog Protein, crystallin gamma D Protein, crystallin, gamma D Protein, crygd.L Protein, CRYGD Protein, Crygd Protein
Hintergrund
Crygd, also known as gamma-crystalin D, belongs to the beta/gamma-crystallin family. Crystallins are the dominant structural components of the vertebrate eye lens. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Gamma-crystallins have been involved in cataract formation. Defects in Crygd are a cause of cataract autosomal dominant (ADC), cataract congenital non-nuclear polymorphic autosomal dominant (CCP), cataract congenital cerulean type 3 (CCA3) and cataract crystalline aculeiform (CACA). Recombinant mouse Crygd protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.