IL-10RA Protein (AA 22-235) (His tag)

Produktnummer ABIN5854217

Produktdetails

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-235

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses IL-10RA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH

Reinheit: > 85 % by SDS - PAGE.

Endotoxin-Niveau: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: Liquid. In phosphate buffered saline (  pH 7.4) containing 10 % glycerol.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Andere Bezeichnung: IL10RA (IL10RA Produkte)

Synonyme: IL10R1 Protein, IL10RA Protein, CD210 Protein, CD210a Protein, CDW210A Protein, HIL-10R Protein, IL-10R1 Protein, IL10R Protein, AW553859 Protein, CDw210 Protein, CDw210a Protein, Il10r Protein, mIL-10R Protein, interleukin 10 receptor subunit alpha Protein, interleukin 10 receptor, alpha Protein, IL10RA Protein, Il10ra Protein

Hintergrund: IL10RA, also known as Interleukin-10 receptor subunit alpha, is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. It has been shown to interact with Interleukin 10 and Janus kinase 1. Recombinant human IL10RA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molekulargewicht: 25.2kDa (220aa) 228-40kDa (SDS-PAGE under reducing conditions.)

NCBI Accession: NP_001549

UniProt: Q13651

Pathways: Growth Factor Binding