APOC1 Protein (AA 27-83) (His tag)

Produktnummer ABIN5853538

Produktdetails

Target: APOC1 (Apolipoprotein C-I (APOC1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-83

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses APOC1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSTPDVSSA LDKLKEFGNT LEDKARELIS RIKQSELSAK MREWFSETFQ KVKEKLKIDS

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: APOC1 (Apolipoprotein C-I (APOC1))

Andere Bezeichnung: APOC1 (APOC1 Produkte)

Synonyme: Apo-CIB Protein, ApoC-IB Protein, ALPCI Protein, LRRG04 Protein, APOC1 Protein, apoc1 Protein, apolipoprotein C1 Protein, apolipoprotein C-I Protein, Apolipoprotein C-I Protein, APOC1 Protein, Apoc1 Protein, apoc1 Protein

Hintergrund: APOC1 is a member of the apolipoprotein C family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. It is mapped to chromosome 19, where it resides within an apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. APOC1 has a length of 57 amino acids normally found in plasma and responsible for the activation of esterified lechitin cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol from tissues. Its main function is inhibition of CETP, probably by altering the electric charge of HDL molecules. Recombinant human APOC1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 9 kDa (80aa) confirmed by MALDI-TOF

NCBI Accession: NP_001636

UniProt: P02654

Pathways: Apoptose