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CCM2 Protein (AA 66-353) (His tag)
CCM2
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 % by SDS - PAGE
SDS
Produktnummer ABIN5853462
Produktdetails
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Target
Alle CCM2 Proteine anzeigen
CCM2
(Cerebral Cavernous Malformation 2 (CCM2))
Protein-Typ
Recombinant
Proteineigenschaft
AA 66-353
Spezies
Alle Spezies für CCM2 Proteine
Human
Quelle
Alle Expressionssysteme für CCM2 Proteine
Escherichia coli (E. coli)
Aufreinigungstag / Konjugat
Dieses CCM2 Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS)
Sequenz
MGSSHHHHHH SSGLVPRGSH MGSEVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAV LSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPES VDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQ HFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A
Reinheit
> 90 % by SDS - PAGE
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
0.5 mg/mL
Buffer
Liquid. 20 mM Tris-HCl buffer ( pH 8.0) containing 20 % glycerol, 1 mM DTT
Lagerung
4 °C,-20 °C,-80 °C
Informationen zur Lagerung
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Antigendetails
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Target
CCM2
(Cerebral Cavernous Malformation 2 (CCM2))
Andere Bezeichnung
CCM2 (CCM2 Produkte )
Synonyme
C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein
Hintergrund
CCM2 provides instructions for making a protein called malcavernin, which strengthens the interactions between cells that form blood vessels and limits leakage from the vessels. It interacts with a number of other proteins to form a complex that is found in the junctions that connect neighboring cells. It helps turn off (suppress) a signaling molecule known as RhoA-GTPase. Recombinant human CCM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Molekulargewicht
34.3kDa (311aa) confirmed by MALDI-TOF
NCBI Accession
NP_001161407
UniProt
Q9BSQ5
Pathways
Cell-Cell Junction Organization
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