CCM2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target Alle CCM2 Proteine anzeigen
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 2
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses CCM2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human Malcavernin (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CCM2 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- Andere Bezeichnung
- Malcavernin (CCM2 Produkte)
- Synonyme
- C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein
- Hintergrund
- This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
- Molekulargewicht
- 48.7 kDa
- NCBI Accession
- NP_113631
- Pathways
- Cell-Cell Junction Organization
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