TREM2 Protein (AA 19-161) (His tag)

Produktnummer ABIN5853402

Produktdetails

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-161

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TREM2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol, 1  mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Andere Bezeichnung: TREM2 (TREM2 Produkte)

Synonyme: TREM-A1 Protein, TREM-B1 Protein, TREM2 Protein, trem-2 Protein, trem2a Protein, trem2b Protein, trem2c Protein, TREM-2 Protein, Trem2a Protein, Trem2b Protein, Trem2c Protein, triggering receptor expressed on myeloid cells 2 Protein, trem-like transcript 2 protein Protein, TREM2 Protein, trem2 Protein, LOC100228399 Protein, Trem2 Protein

Hintergrund: TREM2 is a membrane protein that forms a receptorsignaling complex with the TYRO protein tyrosine kinase bindingprotein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production ofconstitutive inflammatory cytokines. Defects in this gene are acause of polycystic lipomembranous osteodysplasia with sclerosingleukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 20.4kDa (181aa) confirmed by MALDI-TOF

NCBI Accession: NP_061838

UniProt: Q9NZC2